Download a copy of the latest published papers from NRI scientists:

Nutrigenomics and metabolomics will change clinical nutrition and public health practice…

Zeisel, S.H. (2007) Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements of choline. American Journal of Clinical Nutrition 86: 542-548. (PDF)

Study conducted on mice suggests that prenatal exposure to Diethanolamine, a widely used ingredient in many consumer products and several industrial applications, may have a detrimental effect on brain development…

Niculescu, M., Wu, R., Guo, Z.,da Costa, K-A., Zeisel, S.H. (2007) Diethanolamine alters proliferation and choline metabolism in mouse neural procursor cells. Toxicology Sciences 96(2): 321-326. (PDF)

Higher intakes of choline and betaine not protective for incident coronary heart disease…

Bidulescu, A.,Chambless, L.E., Seiga-Riz, A.M., Zeisel, S.H., Heiss, G. (2007) Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. BMC Cardiovascular Disorders DOI:10.1186/1471-2261-7-20. (PDF)

Common genetic variations determine whether a person gets sick when they do not eat enough choline…

Niculescu, M.,da Costa, K-A., Fischer, L., Zeisel, S.H. (2007) Lymphocyte gene expression in subjects fed low-choline diet differs between those who develop organ dysfunction and those who do not. American Journal of Clinical Nutrition 86: 230-239. (PDF)

Genetic variations influence how much of the healthy effects we get from eating broccoli…

Steck, S., Gammon, M., Hebert, J., Wall, D., Zeisel, S.H. (2007) GSTM1, GSTT1, GSTP1, GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. Journal of Nutrition 137: 904-909. (PDF)

Women need less choline than men because estrogen turns on the gene for making choline in the liver…

Resseguie, M., Song, J., Niculescu, M., da Costa, K-A., Randall, T., Zeisel, S.H (2007) Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB Journal DOI: 10.1096/fj.07-8227com. (PDF)

Women need less choline than men because estrogen turns on the gene for making choline in the liver…

Zeisel, S.H (2007) Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life 59(6): 380-387. (PDF)

Women need less choline than men because estrogen turns on the gene for making choline in the liver…

Fischer, L., da Costa, K., Kwock, L., Stewart, P., Lu, T., Stabler, S., Allen, R., Zeisel, S.H. (2007) Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition 85:1275-1285. (PDF)

Dietary intake of choline by pregnant mothers and later by the infant is important for spinal cord and brain development…

Zeisel, S.H. (2006) The fetal origins of memory: the role of dietary choline in optimal brain development. The Journal of Pediatrics DOI: 10.1016/j.jpeds.2006.06.065 (PDF)

The nutrient choline modulates brain development by methylating gene promoters…

Niculescu, M., Craciunescu, C., Zeisel, S.H. (2006) Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB Journal 20:43-49 (PDF)

Common genetic variations determine whether a person gets sick when they do not eat enough choline…

da Costa, K. A., Kozyrez, O., Song, J., Galanko, J., Fischer, L., Zeisel, S.H. (2006) Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB Journal 20: 1336-1344. (PDF)

Effects of eating soy on gene expression depend on whether a person forms equol from soy in the gut…

Niculescu, M., Pop, E., Fischer, L., Zeisel, S.H. (2006) Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared to those who do not. Journal of Nutritional Biochemistry DOI: 10.1016/j.jnutbio2006.06.002. (PDF)

Common genetic variations determine whether a person gets sick when they do not eat enough choline…

Kohlmeier, M., da Costa, K-A., Fischer, L., Zeisel, S.H. (2005) Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proceedings of the National Academy of Sciences USA 44:16025-16030. (PDF)